Studio One 5, Melodyne 5, and M1
If you have an M1 Mac and have tried using Melodyne with Studio One, chances are you probably ran into this screen:
Anyway, long story short, running Studio One on native Apple Silicon makes it so that it can’t detect VST plugins that need Rosetta (like Melodyne).
https://support.presonus.com/hc/en-us/articles/4407850496141
The fix is to run Studio One in Rosetta: